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Continuous Renal Replacement Therapy (CRRT) is the standard of care
for management of critically ill patients with acute renal failure.
Part of the Pittsburgh Critical Care series, Continuous Renal
Replacement Therapy provides concise, evidence-based, bedside
guidance about this treatment modality, offering quick reference
answers to clinicians' questions about treatments and situations
encountered in daily practice. Organized into sections on theory,
practice, special situations, and organizational issues, this
volume provides a complete view of CRRT theory and practice. Tables
summarize and highlight key points, and key studies and trials are
included in each chapter. The second edition has been updated to
include a new chapter on the use of biomarkers to aid in patient
selection and timing, extensive revisions on terminology and
nomenclature to match current standards, and the most up-to-date
information on newly developed CRRT machines.
Comprehensive and clinically relevant, the 3rd Edition of Critical
Care Nephrology provides authoritative coverage of the latest
advances in critical care procedures for patients with renal
diseases or disorders. Using common guidelines and standardized
approaches to critically ill patients, this multidisciplinary
reference facilitates better communication among all physicians who
care for critically ill patients suffering from kidney disease,
electrolyte and metabolic imbalances, poisoning, severe sepsis,
major organ dysfunction, and other pathological events. Offers
detailed discussions of different forms of organ support,
artificial organs, infections, acute illness occurring in chronic
hemodialysis patients, and much more. Places a special emphasis on
therapeutic interventions and treatment procedures for a hands on
clinical reference tool. Presents information clearly, in a format
designed for easy reference - from basic sciences to clinical
syndromes to diagnostic tools. Covers special populations such as
children, diabetic patients, and the elderly. An exceptional
resource for nephrologists, intensivists, surgeons, or critical
care physicians - anyone who treats critically ill renal patients.
Shares a combined commitment to excellence lead by Drs. Claudio
Ronco, Rinaldo Bellomo, John Kellum, and Zaccaria Ricci -
unparalleled leaders in this field. Addresses key topics with
expanded coverage of acute kidney injury, stress biomarkers, and
sepsis, including the latest developments on mechanisms and
management. Provides up-to-date information on extracorporeal
therapies from new editor Dr. Zaccaria Ricci. Expert ConsultT eBook
version included with purchase. This enhanced eBook experience
allows you to search all of the text, figures, and references from
the book on a variety of devices.
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Hemodialysis, When, How, Why (Hardcover)
Biagio Raffaele Di Iorio, August Heidland, Claudio Ronco, Macaulay Onuigbo
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R7,078
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This book with its most comprehensive and illuminating chapters
covers all the relevant areas of hemodialysis practice including
access for hemodialysis, hemodialysis modeling and membranes,
timing of hemodialysis, infections in hemodialysis, the application
of hemodialysis in extra-renal disease, the various formats of
hemodialysis from nocturnal through SLED to apheresis and the
wearable artificial kidney, convective hemodialysis methodologies,
and various clinical aspects of hemodialysis including
protein-calorie-malnutrition, inflammation, haemoglobin stability
and sleep disorders in ESRD patients and so on. Furthermore, the
inclusion of such new topics as the syndrome of rapid-onset end
stage renal disease (SORO-ESRD), and the place of reduced HBV
testing among ESRD patients in regions with less de novo HBV
incidence to cut down on costs of delivery of hemodialysis care
without loss of quality of care, are new paradigms that would play
stronger roles in hemodialysis care, well into the 21st century.
Over the last 10 years the syndrome of severe acute renal failure
has progressively changed in its epidemiology. It is now most
frequently seen in critically ill patients, typically in the
context of sepsis and multiorgan failure. This epidemiologic change
has meant that intensive care physicians and nephrologists must now
work in close cooperation at all times and must take many com plex
issues of prevention, pathogenesis, and management into account
that they did not previously have to tackle. Simultaneously, the
last 10 years have seen the development of major technical and
conceptual changes in the field of renal replacement therapy. There
are now previously unavailable therapeutic options that provide
physicians with a flexible and rapidly evolving armamentarium. The
nutrition of these patients, previously limited by the par tial
efficacy of renal replacement therapies, has also become more
aggressive and more in tune with the needs of critically ill
patients. Increased understanding of the pathogenesis of the multi
organ failure syndrome has focused on the role of many soluble
"mediators of injury" (cytokines, leukotrienes, prostanoids etc.).
These molecules are likely to participate in the pathogenesis of
acute renal failure. Their generation and disposal is also affected
by different techniques of artificial renal support."
This book presents contributions from leading international experts
in the field of nephrology. Each chapter is independent and
discusses nephrology in the author's country, including the history
of nephrology development, kidney disease epidemiology, clinical
nephrology, dialysis practice in acute and chronic renal failure
settings (hemodialysis, hemodiafiltration, peritoneal dialysis),
pediatric nephrology, and kidney transplantation. In addition, the
book covers topics such as the job market for nephrologists,
reimbursement, nephrology education, and the number of
professionals in the private and public sectors. With 53 chapters
and more than 300 authors from all continents offering a unique
perspective on nephrology practice, it provides a much-needed
information source for nephrologists around the globe. The reader
will be able to travel through "Nephrology Worldwide", a pleasant
reading experience with not only relevant information and updated
data, but also a comprehensive look at the history, countries'
peculiarities, and a critical analysis of the scenario of
nephrology and renal replacement therapy. A valuable resource for
healthcare professionals and other stakeholders interested in
learning about the status quo of Nephrology Worldwide. "Both the
failings and the successes are outlined in a way that should make
this book a compelling read, not just for the well-informed renal
physician, but also for planners and policy makers whose thinking
and actions are integral to the way we practice medicine." - Sir
Peter J. Ratcliffe, Nephrologist and 2019 Nobel Prize Winner More
information on the Nephrology Worldwide initiative can be found at
www.nephrologyworldwide.com.
Hyperuricemia is often associated with life-style related disorders
such as diabetes mellitus, hypertension, and dyslipidemia, which,
in turn, are major causes of CKD. Improved management of
hyperuricemia is thus expected to be beneficial for both the
general population and CKD patients. This book presents new
information on uric acid in tubular transport, early recognition of
renal lesions, genetic predisposition, preeclampsia, metabolic
syndrome, diabetes, high blood pressure in the young, and the
relationship with vitamin D. Moreover, the relationship between AKI
and uric acid, as well as the rejection of renal transplants due to
hyperuricemia, are discussed. This publication will be of interest
to both general practitioners and researchers working in the field
of CKD. It provides new insights into renal damage caused by
hyperuricemia and into prevention and treatment possibilities.
The cerebro-renal interaction - a neglected entity Chronic kidney
disease (CKD) is an established risk factor for cardiovascular
diseases. Stroke, on the other hand, is not only a major player in
cardiovascular disease, but it also has strong two-way
relationships with CKD. Moreover, subclinical cerebral
abnormalities are also associated with CKD. But despite all these
connections, the cerebro-renal interaction has so far not received
much attention. This book includes easily understandable reviews on
brain, stroke and kidney by both experts in nephrology and
neurology. Examined are underlying concepts for cerebro-renal
interaction, risk of clinical and subclinical brain damage in CKD
patients, primary prevention and acute/chronic management for
stroke patients with CKD and end-stage kidney disease. This book
promotes not only further understanding and a multidisciplinary
collaboration between nephrologists and neurologists, but it is
also of interest for neurosurgeons and cardiologists.
Acute organ damage and the ensuing multiple organ failure are the
result of a pathophysiological process involving various cytokines.
Once activated, these proteins cannot be eliminated even when the
kidneys function at their maximum capacity. To counteract this
mechanism, researchers in Japan have developed an innovative
concept employing blood purification to remove the overwhelming
cytokines. This book describes the use of hemodiafiltration to
inhibit the cytokine storms which cause serious organ damage in
patients with septic shock. Moreover, the technical construction of
the blood purification system, which includes various machines,
devices, membranes, fluids, etc., is explained in detail. Finally,
leading experts discuss the concept of continuous renal replacement
therapy as the standard care in critically ill patients with severe
acute kidney injury. Describing the current state of acute blood
purification, this publication provides new impulses and opens new
avenues in the treatment of acute organ damage.
We are currently facing an alarming obesity epidemic, with its
well-known health consequences such as metabolic syndrome / type 2
diabetes, cardiovascular diseases, an increased incidence of
certain types of cancer, musculoskeletal disorders and pulmonary
diseases. Experimental and clinical evidence accumulated in recent
years now suggests that obesity has also a major effect on renal
structure and function. Since the adipocyte is considered a source
of many hormones and cytokines, obesity has much more direct
influences on renal function besides mediating hypertension: It can
by itself induce renal disease such as focal segmental
glomerulosclerosis, but also, more commonly, bring about
progression of chronic renal diseases. The present volume is the
first comprehensive compilation dedicated to this important topic,
featuring discussions of pathophysiological as well as clinical
aspects written by the leaders in this emerging field of research.
It brings together pathophysiological concepts on how obesity
influences renal structure and function, reviews the epidemiology
of the problem and provides therapeutic suggestions. This
publication is recommended for internists, nephrologists,
hypertensiologists, cardiologists, and urologists treating patients
with obesity and renal diseases. Furthermore, basic scientists such
as renal physiologists, renal pathologists, pharmacologists,
biochemists, and epidemiologists who want a comprehensive overview
of the topic will also profit from this book.
A compendium of consensus papers, guidelines and research summaries
Associated with both acute kidney injury (AKI) and cardio-renal
syndromes (CRS), new biomarkers represent both a popular area of
investigation and a new opportunity for advancement of therapy.
This book contains the resolutions of the most recent ADQI
conferences on biomarkers in AKI (Dublin) and on cardio-renal
syndromes (Venice). The first part answers specific questions about
new biomarkers and their use and utility in AKI: What are the most
suitable candidate molecules and physiologic measures, how solid
and evidence based is the discovery phase? How can we incorporate
the new biomarkers in the AKI conceptual model describing the
evolution from susceptibility to insult, decreased GFR and organ
death? Even if we have a positive biomarker pattern and we can
identify patients at risk or patients with early or even
subclinical AKI, how is this information affecting our clinical
behavior and practice? The second part is dedicated to the
appraisal of the current knowledge about the pathophysiological
mechanisms involved in different forms of CRS: it contains
contributions on the state-of-the-art knowledge and practice of
CRS, particularly focusing on the pathophysiology of the five
subtypes. Acute and chronic mechanisms of damage are explored in
depth, with particular attention to the primacy of organ
involvement and the subsequent pathways of organ crosstalk.
Presenting the most recent research in the field of biomarkers, AKI
and CRS, this publication is an important educational tool for
advanced investigators and clinical experts, but also for students
and fellows.
Acute kidney injury (AKI) is a serious disorder in which sudden
impairment of kidney function occurs secondary to one or more of a
variety of underlying conditions and exposures. It is very common
in (elderly) ICU patients and associated with very high mortality.
Many of those who survive suffer from permanent kidney failure and
other long-term morbidities. Renowned experts from around the world
have contributed to this new publication, creating a succinct yet
complete review of the most controversial aspects of AKI. The
topics range from epidemiology and basic science to pathophysiology
and clinical issues. It is intended as a concise reference work for
physicians and nurses who deal with AKI in clinical nephrology and
intensive care wards on a daily basis.
Acute kidney injury (AKI) is a serious and as yet incompletely
understood disorder in which sudden impairment of kidney function
occurs secondary to one or more of a variety of underlying
conditions. This disorder is very common in (elderly) ICU patients
and is associated with very high mortality. Many of those who
survive suffer from permanent kidney failure and other long-term
morbidities, which may include cardiovascular disease and immune
dysfunction. Epidemiologic evidence suggests that AKI is not a
single disease, but a syndrome comprised of multiple, often
coexisting, etiologies. Being usually part of multiorgan failure
syndrome, it calls for multiple organ support therapy. The
publication at hand contains sections on prerenal azotemia
syndromes, dying 'of' or 'with' AKI, pathophysiology of
sepsis-induced acute kidney injury, developments in prevention /
treatment / rehabilitation, and renal support. Reporting the latest
recommendations from experts, it provides valuable information for
those that are interested in understanding the disorder and its
treatment options.
This publication contains the most recent findings in the field as
presented by the outstanding faculty of the 2012 International
Vicenza Course on Peritoneal Dialysis. After 30 years, this course
is still one of the main educational events in the field of
peritoneal dialysis as well as other disciplines including CKD,
hemodialysis and critical care nephrology. The publication of the
book in time for the course represents another success of the
Vicenza team. The experts of the world and the related industry met
in Vicenza for this important anniversary which is celebrated by
this book representing not only a milestone in the history of the
Department of Nephrology and the International Renal Research
Institute of Vicenza, but also and above all an extraordinary
educational tool for all physicians and nurses interested in
peritoneal dialysis today.
Uric acid disorders are involved in both nephrological and
hematological diseases. One of these crystal-associated diseases
which has been known since antiquity is gout. More recently, tumor
Lysis syndromes have been identified which affect patients with
cancer, especially in the phase of cellular destruction after
chemotherapy. The detection of these hyperuricemic syndromes,
together with the improved understanding of urate handling by the
kidney, have spurred new interest in the pathophysiology of
hyperuricemic states, their clinical consequences and management.
Moreover, the recent development of a recombinant form of urate
oxidase transforming uric acid into allantoin (Rasburicase) has
caused new interest in the pathophysiology of hyperuricemia and the
potential applications of this new drug. The multidisciplinary
approach of this book offers new insights into the metabolic
syndromes in question by uniting authors from the fields of
biochemistry, pharmacology, rheumatology, onco-hematology, and
nephrology. The result is a compendium of the present knowledge in
the field, which will also be very useful as a reference tool for
professionals and students who want to expand their knowledge on
this topic.
Critical care nephrology is an emerging multidisciplinary science
in which the competences of different specialists are merged to
provide a unified diagnostic and therapeutic approach to the
critically ill patient. The volume at hand places great emphasis on
cardiorenal syndromes and the multidisciplinary collaboration
between cardiology and nephrology. Several contributions describe
the cardiorenal syndrome in its different varieties and subtypes
and report the results from the most recent Acute Dialysis Quality
Initiative Consensus Conference, as well as proposing new
diagnostic approaches based on early biomarkers of AKI. Other
papers discuss advances in technology for renal replacement therapy
and multiple organ support therapy. Moreover, special emphasis is
placed on the potential role of extracorporeal therapies in
patients affected by H1N1 influenza, and a summary of the most
recent trials in the field is included. Containing the proceedings
of the 2010 International Vicenza Course on Critical Care
Nephrology, this publication is a state-of-the-art appraisal of
today's technology and current issues related to cardiorenal
syndromes.
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